Publication alert – A review of non-nucleotide biomarker discovery protocols from body fluids in breast cancer diagnosis
https://doi.org/10.3390/cancers15102780
Breast cancer has now become the most commonly diagnosed cancer, accounting for one in eight cancer diagnoses worldwide.
Various studies and techniques have been designed to discover biomarkers in biofluids, such as saliva, for non-invasive early detection and prognosis of cancers. Despite the importance of this, the reported markers are often inconsistent and irreproducible across different studies and cohorts.
In this article, the authors reviewed the ongoing trend of non-nucleotide biomarkers, including lipidomics, proteomics and metabolomics, derived from body fluids, with a focus on breast cancer. The inconstancies in the biomarker discovery pipelines across pre-analytical, analytical, and post-analytical phases, are reviewed. This covers the diversity of approaches from sample processing to predictive modelling and validation.
Manuscript co-author – Dr Azadeh Safarchi
Collaborative partners
School of Biotechnology and Biomolecular Sciences, University of New South
Wales (UNSW Sydney), Sydney, NSW 2052, Australia
BCAL Diagnostics Ltd., Suite 506, 50 Clarence St, Sydney, NSW 2000,
Australia
BCAL Dx, The University of Sydney, Sydney Knowledge Hub, Merewether
Building, Sydney, NSW 2006, Australia
UNSW Data Science Hub (uDASH), University of New South Wales (UNSW Sydney),
Sydney, NSW 2052, Australia
OmniOmics.ai Pty Ltd., Sydney, NSW 2035, Australia
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View the full manuscript – https://doi.org/10.3390/cancers15102780
See more of Azadeh’s and the human gut health team’s research: