The MOSH Future Science Platform is developing new understanding of microbiome connectivity across the environment to human continuum and how system perturbations impact on microbiome functionality, diversity and systems health.
A key objective of MOSH is to capture greater benefit from microbiome interactions through more informative and predictive frameworks for functionality and by targeted interventions.
Capacity to directly manipulate microbiomes across hosts and environments will provide new opportunities for bio-based solutions to be developed and applied to improve the health of natural and managed environments and for increased benefit to plants, animals and humans.
Central to MOSH is recognition that:
- microorganisms are integral to genotypic & phenotypic makeup of all organisms and environments
- microbiome-mediated interactions are critical for environmental & human function and health
- ‘One Systems Health’ requires that microbiomes interconnect across the entire soil to gut continuum
- microbiome interventions have potential for transformational change through bio-based solutions.
MOSH is developing and exploring new horizon science opportunities directed at:
Systems Connectivity: Application of multi-omic tools to analyse ‘point’ and ‘system’ level change and associated measures of functionality both within and across interconnected biomes. Analysis of common signal pathways and ‘assemble rules’ that interconnect microbiome components (species, genes, pathways) across soil-plant-animal and environmental/urban systems.
Predictive Frameworks: Analysis of the ‘state’ of a microbiome and its response to biotic & abiotic factors that drive structural and functional change. Integration of multi-faceted data layers and empirical and statistical modelling to measure and predict how systems perturbations influence microbiome resilience, functionality and the resultant impact on host and environmental health.
Deliberate Interventions: Develop technologies to ‘construct’ novel microbiome communities and manipulation of microbiome communities for an intended benefit. Use of management interventions to deliberately modify microbiome-host/environment interactions for targeted outcomes that are predictable, effective and provide stabilized microbiome function.
MOSH will deliver outcomes directed at a number of key focal areas over 4 application domains that sit across CSIRO’s impact area science portfolio, including:
- environment, soil & plant health: to support systems health in response to biotic & abiotic stresses and system pertubations across diverse and interconnected environments
- food chain & production: to facilitate agricultural systems and food-chain value for improved plant and animal production efficiencies and implementation of novel food interventions
- food, gut and health: to promote a diverse and functionally healthy state of the gut with associated capacity to manipulate the gut for stable and improved health and wellbeing
- industry & urban systems: to develop new approaches to support bio-industrial processing, waste management and bio-based solutions for ecosystem remediation and management
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