The MOSH Future Science Platform is developing new understanding of microbiome connectivity across the environment to human continuum and how system perturbations impact on microbiome functionality, diversity and systems health.
A key objective of MOSH is to capture greater benefit from microbiome interactions through more informative and predictive frameworks for functionality and by targeted interventions.
Capacity to directly manipulate microbiomes across hosts and environments will provide new opportunities for bio-based solutions to be developed and applied to improve the health of natural and managed environments and for increased benefit to plants, animals and humans.
Central to MOSH is recognition that:
- microorganisms are integral to genotypic & phenotypic makeup of all organisms and environments
- microbiome-mediated interactions are critical for environmental & human function and health
- ‘One Systems Health’ requires that microbiomes interconnect across the entire soil to gut continuum
- microbiome interventions have potential for transformational change through bio-based solutions.
Discover MOSH’s microbiome research in key focal areas and how we are harnessing the invisible and invaluable microbes to enhance our food, environment and health:
Human gut microbiome
Enhancing the human gut microbiome to promote long-term health outcomes and disease prevention.
Insect gut microbiome
Enhancing the gut microbiome of insects to enable them to reduce waste in our environment.
Plant health microbiome
Using multi-omic techniques to better understand how plants interact with their microbiome and how it impacts plant health.
Contaminated environment microbiomes
Development of designer microbiomes for the bioremediation of contaminated environments and waste reduction.
Animal production microbiome
Understanding the cattle microbiome to promote happier, healthy cows that require less antibiotic and chemicals.
Bacteriophage-mediated transfer of antibiotic resistance genes
Bacteriophages are viruses that infect and can kill bacteria, and are currently considered a promising solution to overcome antibiotic resistance. See how researchers are developing the knowledge that could control the spread of these harmful genes from the environment to humans and animals.
MOSH is developing and exploring new horizon science opportunities directed at:
Systems Connectivity: Application of multi-omic tools to analyse ‘point’ and ‘system’ level change and associated measures of functionality both within and across interconnected biomes. Analysis of common signal pathways and ‘assemble rules’ that interconnect microbiome components (species, genes, pathways) across soil-plant-animal and environmental/urban systems.
Predictive Frameworks: Analysis of the ‘state’ of a microbiome and its response to biotic & abiotic factors that drive structural and functional change. Integration of multi-faceted data layers and empirical and statistical modelling to measure and predict how systems perturbations influence microbiome resilience, functionality and the resultant impact on host and environmental health.
Deliberate Interventions: Develop technologies to ‘construct’ novel microbiome communities and manipulation of microbiome communities for an intended benefit. Use of management interventions to deliberately modify microbiome-host/environment interactions for targeted outcomes that are predictable, effective and provide stabilized microbiome function.
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