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Research

CSIRO’s state-of-the-art flow chemistry laboratory features a variety of flow reactors and ancillary equipment that can be used to address all stages of the R&D pipeline, including discovery, process development, and scale-up (pilot and industrial).

FloWorks operates a broad range of different laboratory scale and production scale continuous flow reactors and chemical process equipment, ranging from a few mL to several L in reactor volume. We are closely working together with a range of commercial equipment suppliers in order to optimise reactor design and process efficiency, including Cambridge Reactor Design, Chemtrix BV, Vapourtec Ltd., and others. Building on several years experience operating this technology, we can devise efficient chemical processes using off-the shelf reactor solutions from one of our collaborating equipment manufacturers or design new tailor-made chemical reactors, dedicated for a specific operation. We also develop novel reactor concepts for a range of common chemical processes, such as heterogeneous catalysis and multi-phase reactions, with the aim to improve on established manufacturing procedures.

We can develop new chemical routes from laboratory discovery to continuous flow production scale or transfer existing inefficient batch procedures into continuous processes and offer in-house training for industrial collaborators on our state-of-the-art flow chemistry equipment.

Some of our recent publications:

Poylmers: “Continuous Flow Aminolysis of RAFT Polymers Using Multistep Processing and Inline Analysis”, C. H. Hornung, K. von Känel, I. Martinez-Botella, M. Espiritu, X. Nguyen, A. Postma, S. Saubern, J. Chiefari, and S. H. Thang, Macromolecules, 2014, 47, 8203–8213, doi:10.1021/ma501628f.

MOFs: “Versatile, High Quality and Scalable Continuous Flow Production of Metal-Organic Frameworks”, M. Rubio-Martinez, M. P. Batten, A. Polyzos, K.-C. Carey, J. I. Mardel, K.-S. Lim, and M. R. Hill, Sci. Rep., 2014, 4, 5443,  doi:10.1038/srep05443.

Medchem: “Flow Synthesis of Tricyclic Spiropiperidines as Building Blocks for the Histrionicotoxin Family of Alkaloids”, M. Brasholz, B. A. Johnson, J. M. Macdonald, A. Polyzos, J. Tsanaktsidis, S. Saubern, A. B. Holmes, and J. H. Ryan, Tetrahedron, 2010, 66, 6445-6449, doi:10.1016/j.tet.2010.04.092.

Dyes and Chemicals: “A Two Stage, Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes”, Mark York, Adriana Edenharter, Aust. J. Chem., 2012, 66, 172–177, doi:10.1071/CH12435.