Probing Biosystems is a multi-year investment between CSIRO and our partners to develop innovative platforms that enable real-time interrogation of living biological systems in order to extract meaningful and actionable information about their health and well-being.
A key requirement in the advance towards precision health and medicine is our ability to monitor, in real time, the many complex physiological processes occurring within the human body. These processes can be early warning signs of injury or disease. The ability to detect subtle changes in physiological function, disease-specific biomarkers, or exposure to harmful pathogens enables the earliest of interventions, ensuring life quality keeps pace with life expectancy.
The Probing Biosystems Future Science Platform (FSP) has been established to tackle these challenges. Probing Biosystems is a collection of 13 projects set to revolutionise the healthcare and biosecurity of the nation through the development of medical devices and model systems to obtain real-time information about health and well-being. CSIRO’s multidisciplinary teams are working with industry and academic partners on research leading to the provision of health and medical interventions that are timely, customised and highly specific. These projects are being developed within four research themes: Health Surveillance, In vitro Diagnostics, Model Systems and Precision Nanomedicine.
The Probing Biosystems future science platform, led by Prof Stephen Rose, is hosted by the CSIRO Health and Biosecurity business unit and partners with Manufacturing, Data 61, AAHL, Minerals and Land & Water.
Neurocybernetics for Patients with Head Injury
Test Bed Vision: “To develop world first cranial implants with biosensors to measure temperature, pressure and electrical activity in real time to monitor patients during and after cranial surgery” Cerebral oedema (excess fluid) and intracranial hypertension (pressure within the skull) are among the most fundamental pathophysiological processes occurring in neurologic conditions including: haemorrhage, traumatic brain […]
Wearable Nanoneedle Biosensors
Test Bed Vision: “To apply nanoneedle array sensor technology to detect markers of tumour recurrence” The need for rapid accurate diagnosis of metastatic disease has become a major priority to facilitate more timely and efficacious intervention. This project aims to extend our silicon nanoneedle array platform to enable detection of specific cancer biomarkers from the […]
In Vitro Diagnostics
Test Bed Vision: “Early and accurate cancer and disease diagnosis can save lives” Diagnosing cancers and other diseases at early stages can save lives. For example, diagnosing lung cancer at Stage IIA rather than Stage IV increases five-year survival from 13% to 46%. That would save thousands of lives a year in Australia. Similarly, early […]
Early Asthma Detection
Test Bed Vision: “To detect the onset of asthma before an attack to improve management of asthma” The onset of an asthma attack can seemingly come out of nowhere. Only when a person is struggling for breath does the management of the attack take place through an inhaler or other course of treatment. Sometimes that’s […]
Saliva Biomarkers of Ageing and Health
Test Bed Vision: “The future of human health resides in innovative platforms such as implantable biosensors and point-of-care devices that can extract real time information on the health status of individuals.” The integrity of our DNA is under constant threat from the accumulation of damage due to the progression of ageing. Damage to DNA can […]
Monitoring Brain Cell Death in Brain Injury
Test Bed Vision: “To develop a point-of-care diagnostic device by measuring cell-free DNA from dying neurons associated with traumatic brain injury” It is difficult to diagnose mild traumatic brain injury (TBI) using conventional CT and MRI scanning. There is an overwhelming clinical need for a rapid in improve diagnoses and guide treatment, particularly for diffuse […]
Lethal Virus Detection
Test Bed Vision: “To develop next generation diagnostic tools for the early detection of viral encephalitis” It’s a tragic story that hospitals see all too often of a child appearing at the Emergency Room with a signs of what could be a mild viral infection. By the time the symptoms are severe enough to indicate […]
Faster Responses to Infectious Pandemics
Test Bed Vision: “To develop a capability to fast-track disease diagnosis and preclinical testing to reduce the impacts of emerging infectious disease” From the Black Death to the Spanish influenza, Infectious disease pandemics have occurred regularly over history. Thanks to air travel and globalisation they are appearing at an increasing frequency. Now more than even […]
Gastrointestinal Screening for Better Gut Health
Test Bed Vision: “To develop a screening tool to optimise diagnostic, prevention and therapeutic strategies of gut health” With incidents of bowel cancer rising and more people suffering from coeliac disease and inflammatory bowel disease and syndrome, there is plenty of attention on gut health. Colorectal cancers are the second most common cancer in Australia […]
Next Generation of Virus Biosensors
Test Bed Vision: “To create the next generation of biosensors to control the spread of animal virus disease” Infectious disease in livestock is a very serious concern for animal-based food production. An outbreak could have enormous repercussions across the industry. Not just in terms of costs but in terms of the viability of a secure […]
Brain Organoid on a chip
Test Bed Vision: “To develop a highly predictive experimental platform to enable high throughput screening of CNS drugs” Central nervous systems disorders, such as brain cancer and viral encephalitis severely affect individuals while therapeutic possibilities remain limited. The slow evolvement of successful therapeutics targeting central nervous system are due to the blood-brain barrier and drug […]
Infection and Inflammation 3D Tissue Models
Test Bed Vision: “To develop 3D soft tissue model systems capable of responding to a variety of infection and/or inflammatory challenges” This project aims to use skin tissue engineering as the basis for the development of an immune-competent in vitro 3D model capable of evaluating a wide range of external challenges. The 3D infection and […]
Improved Delivery of Therapy for Brain Cancer
Test Bed Vision: “To develop a novel platform for treating patients with brain cancer using more targeted and localised treatments” Brain cancers are currently the highest cause of cancer death in patients under 40. Current treatment paradigms include maximal surgical research followed by radiation therapy and adjuvant chemotherapy but despite technological advances over the past […]