Therapeutic Noble Gases

Therapeutic Noble Gases was a project with Air Liquide aimed to discover the therapeutic potential of noble gases. We took a massive online database of 140,000 protein structures and used computer modelling to show how noble gases would interact with them at the molecular level. We’ve created an intuitive, interactive online visualisation platform to help medical researchers interact with the data and make their own discoveries. It’s an example of how CSIRO partners with industry to address research challenges, and help create a better future for everyone.

See Press Release: Noble Quest Clearing the Air Over Potentially Life-Saving Gases

References

Identifying Medically Relevant Xenon Protein Targets By In Silico Screening of the Structural Proteome
Medical Gas Research – 2022
David A. Winkler, Ira Katz, Aaron W. Thornton and Geraldine Farjot

Massive in Silico Study of Noble Gas Binding to the Structural Proteome
Journal of Chemical Information and Modelling – 2019
David A. Winkler, Andrew C. Warden, Terry Prange, Natalie Colloc’h, Juan-Fernandez Ramirez-Gil, Aaron W. Thornton, Geraldine Farjot and Ira Katz

Decoding the Rich Biological Properties of Noble Gases: How Well Can We Predict Noble Gas Binding to Diverse Proteins?
ChemMedChem – 2018
David A. Winkler, Ira Katz, Geraldine Farjot, Andrew C. Warden and Aaron W. Thornton

The Diverse Biological Properties of the Chemically Inert Noble Gases
Pharmacology & Therapeutics – 2016
David A. Winkler, Aaron W. Thornton, Geraldine Farjot and Ira Katz