Detailed immune analysis using African swine fever virus as a model
Dr Quentin Wright
Understanding the complexity of the immune system’s response to infection and vaccination is an important step in learning how to control disease.
The immune system is composed of several cell subtypes, many of which are not stimulated by infection and can mask the processes of the immune system’s response to infection.
Currently, scientists are required to perform multiple experiments to comprehend an immune response.
The aim of this project is to create a higher resolution immune cell analysis methodology. To achieve this, we will be utilising single cell multi-omics technology, measuring multiple types of molecules from the same cell, providing greater insight into how a cell operates during an immune response.
Initially, we will focus our studies on African swine fever virus and and investigate the immunological pathways triggered in response to infection.
The long term aim is to develop a methodology capable of generating a comprehensive analysis of the immune response to infectious diseases at single-cell resolution and which can be applied across multiple species.
Project lead: Dr Quentin Wright