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Screening

Nano Volume Screening

Our Advantage

The Collaborative Crystallisation Centre’s advantage is that our technology allows us to set up thousands of unique experiments per day. Using robotic technology lets us conduct smaller-scale experiments (10x less sample) than in a typical manual experiment, in doing this we can complete a wider range of experiments with the same amount of sample.

USER GUIDE: Novice Guide
USER GUIDE: Access C3

Nano-screening

We offer over 20 crystallisation screens of commercial and non-commercial origin, offering a wide variety of initial screening conditions. All of the screens are formatted into 96 wells (8 x 12 array), and are made in-house to ensure that we have the stocks to make up fine screens around any hit you might see.

Our crystallisation plates are based on vapour diffusion technology and are designed for up to 192 nano-scale experiments. The size of the drops is large enough for crystals to be harvested for diffraction studies.

Automated Imaging

The plates are incubated at either 20 or 8ºC and imaged on a diminishing schedule over 2 months, which includes UV inspections. You are able to collect the plates at any point during the incubation period (collecting plates).
The images associated with each plate are made available using an online viewing application.