CSIRO’s Gene to C3 to Structure

Gene to C3 to Structure

A gene to structure campaign is not a core service offered by the C3.

However, we are embedded with the CSIRO research groups & facilities that can complete this, and the C3 is an appropriate point of contact.

If you’d like to know more, please email us.

Protein Expression & Purification

• Numerous tested & customizable expression systems
• Rigorous and highly flexible purification workflows
• Soluble and membrane protein production
• Strict quality control (PAGE, Chromatography, Mass Spec)

Protein Crystallization & Structural Biology

• High-Throughput protein crystallization screening
• On the go “hit” verification & optimization
• Reliable access to the Australian Synchrotron for data collection
• Structure determination and refinement

Biophysical Characterization

• Differential Scanning Fluorimetry (DSF – Thermal Shift)
• Surface Plasmon Resonance Spectroscopy (SPR)
• Isothermal Titration Calorimetry (ITC)
• Temperature controlled (4-70C) Dynamic Light Scattering (DLS)
• Matrix Assisted Laser Desorption / Ionization Time-of-Flight (MALDI-ToF)

Fragment Screening & Drug Design

• Ready access to trusted fragment libraries
• In-house medicinal chemists
• In-silico candidate optimization and design