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CSIRO’s Gene to C3 to Structure

Gene to C3 to Structure

A gene to structure campaign is not a core service offered by the C3.

However, we are embedded with the CSIRO research groups & facilities that can complete this, and the C3 is an appropriate point of contact.

If you’d like to know more, please email us.

Protein Expression & Purification

  • Numerous tested & customizable expression systems
  • Rigorous and highly flexible purification workflows
  • Soluble and membrane protein production
  • Strict quality control (PAGE, Chromatography, Mass Spec)

Protein Crystallization & Structural Biology

  • High-Throughput protein crystallization screening
  • On the go “hit” verification & optimization
  • Reliable access to the Australian Synchrotron for data collection
  • Structure determination and refinement

Biophysical Characterization

  • Differential Scanning Fluorimetry (DSF – Thermal Shift)
  • Surface Plasmon Resonance Spectroscopy (SPR)
  • Isothermal Titration Calorimetry (ITC)
  • Temperature controlled (4-70C) Dynamic Light Scattering (DLS)
  • Matrix Assisted Laser Desorption / Ionization Time-of-Flight (MALDI-ToF)

Fragment Screening & Drug Design

  • Ready access to trusted fragment libraries
  • In-house medicinal chemists
  • In-silico candidate optimization and design