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Other Crystallisation Centres

These are other facilities around the world that offer services for macromolecular crystallisation. Blurbs for each centre have been taken from their respective websites.

Biocenter Finland Crystallisation Facility
Helsinki, Finland

Robots are key to the expansion of macromolecular crystallography. They can accurately handle nanolitre volumes and so do the crystallisation experiments with only 5-10% of the protein required for manual setup. The small drops also equilibrate faster allowing faster analysis of the results. More…

CEITEC Biomolecular Interactions and Crystallization
Brno, Czech Republic

The core facility provides services leading to structure characterization of biomolecules and to study (bio)molecular interactions in a real time using mainly biosensor and calorimetry-based methods. It is equipped with the instrumentation to set up crystallization conditions of biomolecules and their complexes, basic characterization of physical properties of the molecules (analytical ultracentrifugation, dynamic light scattering, CD spectroscopy, differential scanning calorimetry), and to study thermodynamics and/or kinetics of interactions (isothermal titration calorimetry, surface plasmon resonance, CD spectroscopy, analytical ultracentrifugation). More…

EMBL Highthroughput Crystallization Facility
Hamburg, Germany

The Sample Preparation and Characterization facility (SPC) is located directly next to the EMBL beamlines at the PETRA III synchrotron. We offer a pipeline from the lab bench to our X-ray and SAXS beamlines, helping you to optimize and prepare your samples for structural studies. Our high-throughput crystallization laboratory offers initial crystallization screens from various suppliers as well as customized screens for optimization of initial hits, both suitable for soluble and membrane proteins. More…

Hauptman-Woodward High-Throughput Crystallization Center
New York, United States of America

Our facility offers instrumentation and the technical expertise required to express and purify milligram quantities of soluble and membrane proteins for biophysical and structural characterization. At the core of our facility is a high-throughput screening laboratory for use in the identification of initial crystallization leads for a target protein. The laboratory uses two sets of 1536 crystallization cocktails for soluble and membrane proteins, set up using the microbatch-under-oil crystallization technique. We monitor experiments using digital recordings of the results. Full laboratory facilities are available for the identification of protein crystals, optimization of crystallization leads and structure determination using X-ray crystallography. More…

Max Planck Institute of Biochemistry
Munich, Germany

The facility offers high-throughput screening for crystallization conditions, an automated plate storage and imaging system for the experiments at 4°C and 20°C, an advanced liquid handling robot for a fast and reproducible crystal optimization, and a PX scanner for in situ diffraction tests of crystals. More…

Monash Macromolecular Crystallisation Facility
Victoria, Australia

Macromolecular crystallography provides unparalleled details of the 3D structures of biological macromolecules and provides the basis for the rational design of therapeutics. The Monash Macromolecular Crystallisation Facility provides access to a fully automated platform for the high-throughput crystallisation of biological macromolecules. The use of robotics allows for miniaturisation of crystallisation experiments, which enables screening of a wide range of conditions using limited sample volumes. More…

MRC-LMB Crystallisation Facility
Cambridge, United Kingdom

MRC plates containing crystallisation initial screens from various suppliers are made freely available (80 µl of a condition in each reservoir). Drops are set with nanolitre dispensing robots (mainly TTP’s MOSQUITO). A common approach is single drops of 200 nl final volume with 1:1 ratio (100 nl protein + 100 nl condition). The user will then need 336 µl of sample when preparing the 21 LMB plates (16 µl per plate; 2,016 initial conditions in total). A fully automated system can be used for setting up drops, although more sample is required compare to proceeding with stand-alone robot (22 µl per plate). Other protocols are available (different volumes/ratios, 2 drops, seeding, etc). More…

Nanoliter Crystallization Facility
Minnesota, United States of America

We can take a purified protein/nucleic acid and do all of the crystallization experiments, keep track of the data and optimize the procedure to produce diffraction quality crystals; or support an investigator in setting up crystallization experiments that they design design themselves. We can assist you in preparing a protein/nucleic acid sample for crystallization. We are available to consult on difficult crystallization projects. More…

OPPF
Oxford, United Kingdom

The OPPF provides access to a high-throughput crystallization pipeline. Crystallization experiments are carried out in 96-well Greiner plates using nanolitre-scale droplets (typically 100 nL of protein + 100 nL of reagents). Crystallization plates are stored and imaged at regular intervals at either 4°C or 21°C in automated storage systems. Images are accessible to the users via a web-interface. More…

Paul Scherrer Institut
Villigen, Switzerland

The Macromolecular Crystallisation Facility at the PSI is maintained by the SLS and the BIO division. The facility is situated at the X06DA beamline. We work with scientists from the BIO division, the SLS, the SwissFEL, and elsewhere, to produce and to optimise macromolecular micro- and nano-crystals for x-ray diffraction experiments at the forefront of structural biology. The facility is equipped for robotic crystallization screening using sitting-drop vapour diffusion or lipidic cubic phase; and to image, analyse, optimise, mount and test crystals grown in those experiments. More…

Protein Crystallization Center, Dept. of Biochemistry, University of Zurich
Zurich, Switzerland

The Protein Crystallization Center – PCC@UZH – supports the structural biology research community by setting up and monitor high-throughput protein crystallization experiments at the nano-liter scale. PCC@UZH offers as a service a wide range of crystallization techniques for soluble and membrane proteins. The crystallization service is open to all academic research groups and to private industry. More…

UCLA-DOE Crystallisation Core
Los Angeles, United States of America

The X-ray Crystallography Condition Screening Core Technology Center provides state-of-the-art, high-throughput, crystallization services to all institutions. The full-service core offers access to sophisticated equipment and technologies, and technical assistance in sample preparation. The facility will provide screen preparation, plate setup, and optimization of the resulting crystals. Our high-throughput core can produce 18,000 experiments in a single day. We work in conjunction with the X-ray Crystallography Technology Center, which collects diffraction data and screens crystal quality. More…

University of Liverpool Protein Crystallisation Facility
Liverpool, United Kingdom

The Protein Crystallisation Facility at the Institute of Integrative Biology provides state of the art capability and expertise to help researchers study the three-dimensional structures of biomolecules. More…

University of Southhampton Macromolecular Crystallisation Facility
Southhampton, United Kingdom

The Macromolecular Crystallisation Facility within Biological Sciences and part of the Southampton Diffraction Centre (SDC) provides a pipeline of robotics to carry your biomolecule through crystallisation, optimisation using bespoke screen designs and crystal imaging using state of the art UV detection to distinguish biomolecules from salt. Data collection is carried out either in-house at the SDC or at synchrotron facilities at Diamond near Oxford, or Grenoble. Data processing and structure refinement here in Biological Sciences completes the story. More…

UQROCX Crystallisation Facility
Queensland, Australia

UQ ROCX provides access to world-class equipment for protein crystallisation and diffraction studies to solve crystal structures. Services include protein crystallisation condition screening and optimisation, crystal diffraction screening, data collection, data processing, and structure determination. Nano-litre liquid handlers and automated imaging means that large numbers of crystallisation conditions can be investigated with small quantities of protein. More…

 

*All information current as of publication (June 2017)*